The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase
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چکیده
منابع مشابه
3-Coumaranone derivatives as inhibitors of monoamine oxidase
The present study examines the monoamine oxidase (MAO) inhibitory properties of a series of 20 3-coumaranone [benzofuran-3(2H)-one] derivatives. The 3-coumaranone derivatives are structurally related to series of α-tetralone and 1-indanone derivatives, which have recently been shown to potently inhibit MAO, with selectivity for MAO-B (in preference to the MAO-A isoform). 3-Coumaranones are simi...
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To develop a new more accurate spectrophotometric method for detecting monoamine oxidase inhibitors from plant extracts, a series of amine substrates were selected and their ability to be oxidized by monoamine oxidase was evaluated by the HPLC method and a new substrate was used to develop a peroxidase-linked spectrophotometric assay. 4-(Trifluoromethyl) benzylamine (11) was proved to be an exc...
متن کاملA Peroxidase-linked Spectrophotometric Assay for the Detection of Monoamine Oxidase Inhibitors
To develop a new more accurate spectrophotometric method for detecting monoamine oxidase inhibitors from plant extracts, a series of amine substrates were selected and their ability to be oxidized by monoamine oxidase was evaluated by the HPLC method and a new substrate was used to develop a peroxidase-linked spectrophotometric assay. 4-(Trifluoromethyl) benzylamine (11) was proved to be an exc...
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ژورنال
عنوان ژورنال: Molecular Diversity
سال: 2020
ISSN: 1381-1991,1573-501X
DOI: 10.1007/s11030-020-10143-w